Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Allosteric regulation of KSR2. A regulatory RAF interacts with KSR in cis to induce a conformational switch on MEK to expose its activation loop, subject to phosphorylation by RAF in trans. In the KSR2–MEK1 hetero-tetramer (left), the inaccessible activation segment of MEK1 is released through the interaction of KSR2 with RAF, induced by a conformational change, allowing a “catalytic” RAF to phosphorylate MEK (right).
