Table 1.
Salivary proteins of arthropods.
| Name | Function | SF | Ts | Tr | Reference |
|---|---|---|---|---|---|
| Apyrase/5′Nucleotidase | Hydrolyze ATP into ADP, which is an inducer of platellet agregation | X | (34) | ||
| X | (38) | ||||
| X | (39) | ||||
| Proteases | Hydrolysis of peptide bonds | (34) | |||
| – Metalloprotease | X | X | (39) | ||
| – Serine protease | X | (38) | |||
| Protease inhibitor domains | Interact with the proteolytic cascade of the host homeostatic and inflammatory processes | (34) | |||
| – Serpstands for serine protease inhibitor | X | (38) | |||
| – Kazal domain | X | (40) | |||
| – Thrombinhibitor | X | (39) | |||
| – Kunitz domain | X | (39) | |||
| Antigen 5-like | Unknown | X | (41) | ||
| X | X | (42) | |||
| X | X | (38) | |||
| Endonuclease | Endonucleases are enzymes that cleave the phosphodiester bond with a polynucleotide chain | X | X | (34) | |
| Hyaluronidase | Hyaluronidase hydrolyzes components of the skmatrix | (39) | |||
| Adenosine deaminase purine hydrolase | Hydrolization of adenosine into inosine and then hypoxanthine plus ribose. Adenosine and inosine induce mast cell degranulation and trigger itching reaction | X | X | (34) | |
| X | X | (39) | |||
| Phospholipase | Hydrolysis the platelet agregation factor | X | X | (39) | |
| 33 kDa familly | FXa clotting inhibitor | X | (34) | ||
| Nitrophorin | X | X | |||
| 15–17 kDa familly | Unknown | X | X | (34) | |
| (38) | |||||
| Pyrophosphatase/Phosphodiesterase | Hydrolyze dinucleotides that are important inflamatory mediators | X | (34) | ||
| Glycosydase | Carbohydrate catabolism | X | (34) | ||
| Antimicrobial peptides | X | (34) | |||
| Odorant binding protein/D7 superfamilly | Antagonize inflammation and hemostasis | X | (34) | ||
| Yellow phlebotominae family | Dopachrome convertase activity | X | (34) | ||
| 41.9 kDa superfamilly | Unknown | X | (34) | ||
| Maxadilan | Vasodilatator | X | (34) | ||
| 27–30 kDa | Unknown | X | (34) | ||
| Possibly multigenic Glossina-specific salivary secreted protein | Unknown | X | (39) | ||
| GE-rich salivary proteins | Unknown | X | (39) | ||
| Glycine-proline rich familly | Unknown | X | (39) | ||
| Fat body and salivary 20 kDa family | Unknown | X | (39) | ||
| 3–6 kDa salivary peptide | Unknown | X | (39) | ||
| Ribonucleases | Catalyze the degradation of RNA | X | (39) | ||
| Exonucleases | Endonucleases are enzymes that cleave the phosphodiester bond at the 5′ or 3′ end of the chain | X | (39) | ||
| ProstaglandE2 Synthase | PGE2 synthesis which is a vasodilatator | X | (39) | ||
| Nitric oxyde synthase | Synthesis of nitric oxyde: vasodilatator | X | (39) | ||
| Thioester containing protein | Has a reactive cysteine that can form a thioester bond to other, Pathogen, molecules | X | (39) | ||
| Fibrinogen domacontaining/ficolproteins | Familly of proteins having the Fibrinogen C motif and Ficoli motif | X | (39) | ||
| Inositol phosphatase | Hydrolysis of inositol phosphate and phosphoinositidesubstrates involved cellular process related to signal transduction, secretion, and cytoskeletal structure | X | (43) | ||
| X | (38) | ||||
| Peptidoglycan recognition protein | Pathogen recognition and initiation of innate defense mechanism | X | (39) | ||
| Salivary proteMYS2 | Unknown | X | (38) | ||
| Lipocalin | The term lipocal means « cup of lipid »; they have the capacity to transport small hydrophobic molecules | ||||
| – RPAI | Inhibitor of platelet agregation | X | (43) | ||
| – Triplatin | Antiplatelet, vasodilatator | X | (35) | ||
| – Triafestin | Anti-clotting, antipain | X | (44) | ||
| – Pallidipin | Antiplatelet | X | (45) | ||
| – Triabin | Anti-clotting | X | (46) | ||
| – Procalin | Unknown | X | (47) | ||
| – Dipetalodipin | Antiplatelet, vasodilatator | X | (48) | ||
| – Nitrophorin | Antihistamine | X | (32) | ||