Figure 3.

GluN2B deletion did not impact anxiety-related behavior in the EPM, nor did it affect FLX's ability to lower immobility in the TST. In the EPM, no difference among groups was observed in open arm exploration as measured by (A) time spent in the open arms, (B) number of open arm entries, or (C) distance traveled in the open arms. (D) The total distance traveled in the maze did not differ among groups. (E) In the TST, VEH-treated mice display increasingly higher levels of immobility as the test progresses, while FLX reduced immobility over time. (F) GluN2B deletion did not impact FLX's ability to lower immobility during the last 2 min of the test. ^*p < 0.05, ^**p < 0.01.