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. Author manuscript; available in PMC: 2016 May 31.
Published in final edited form as: JAMA Ophthalmol. 2013 Feb;131(2):194–204. doi: 10.1001/2013.jamaophthalmol.271

Figure 4.

Figure 4

Histologic changes of optic nerve after posterior ischemic optic neuropathy (PION). Posterior optic nerves appear normal 3 days after sham control surgical procedures (laser only/no erythrosin B) (A and D). B, However, 3 days after PION, an area of tissue edema is present. C, Atrophy and degenerative changes appear in posterior optic nerves 2 weeks after PION induction. E, Higher magnification of the boxed region in part B reveals swollen cells and caverns (arrows) within the edema area. F, Higher magnification of the boxed region in part C shows marked degeneration of neural tissue in the infarct region, producing an appearance resembling cavernous degeneration (arrow). Scale bars=100 μm.