Fig. 3.

Nucleotide sequence of the 5’-flanking region of the human TP53 gene. The nucleotide sequence of the 551-bp fragment that was obtained from PCR is shown. The most-upstream 5’-end of the TP53 cDNA (NM_001276760.1, NM_001276761.1, NM_001276696.1, NM_001276695.1 and NM_001126118.1) is designated nucleotide +1. Putative transcription factor-binding sites (TF-SEARCH score > 87) are indicated by dotted arrows. Boxes represent CdxA sequences. Italic and underlined characters represent the cDNA sequences that overlap the human TP53 (Gene ID: 7157) and WRAP53 (GENE ID: 55135) genes, respectively.