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Mutation analysis on c-Ets, Nkx-2.5 and E2F binding elements in the 551-bp human TP53 promoter region. Similar experiment as described under the legend to Fig. 4 was carried out with pGL4-TP53-551, pGL4-TP53-mE2F, pGL4-TP53-mNkx, pGL4-TP53-mEts and pGL4-TP53-mEtNk. Histograms show fold induction of Luc activities by Rsv (20 µM) for 24 h treatment. Results are shown as means ± SD from four independent experiments.
