Table 3.
Sensitivity analysis
| Risk factor | Number of studies included | OR or mean difference [95% CI] | p value for interaction | Inconsistency I2, % |
|---|---|---|---|---|
| Preoperative | ||||
| Age | 11 | 4.87 [3.50, 6.24] | <0.00001 | 79 |
| Diabetes | 11 | 1.52 [1.07, 2.16] | 0.02 | 87 |
| Hypertension | 6 | 1.68 [1.44, 1.97] | <0.00001 | 61 |
| Cerebrovascular disease | 6 | 2.13 [1.11, 4.09] | 0.02 | 90 |
| Respiratory system disease | 7 | 1.29 [1.10, 1.50] | 0.001 | 90 |
| Peripheral vascular disease | 6 | 1.31 [1.09, 1.57] | 0.004 | 73 |
| NYHA III/IV | 6 | 2.53 [1.32, 4.86] | 0.005 | 90 |
| Serum creatinine | 4 | 0.66 [0.18, 1.14] | 0.007 | 97 |
| BMI | 4 | 0.17 [–0.24, 0.58] | 0.42 | 1 |
| EF | 3 | −0.81 [–2.48, 0.85] | 0.34 | 0 |
| Acute myocardial infarction | 6 | 1.11 [0.94, 1.31] | 0.22 | 76 |
| Operative | ||||
| Aortic cross-clamping time | 5 | 13.24 [7.78, 18.69] | <0.00001 | 75 |
| CPB time | 12 | 33.78 [23.15, 44.41] | <0.00001 | 93 |
| Use of IABP | 9 | 4.44 [2.37, 8.30] | <0.00001 | 93 |
| Type of surgery | 8 | 1.01 [0.43, 2.39] | 0.97 | 96 |
| Postoperative | ||||
| Infection | 6 | 3.58 [1.43, 8.97] | 0.007 | 93 |
| Emergency operation | 9 | 4.76 [3.05, 7.43] | <0.00001 | 88 |
| Redo operation | 8 | 2.57 [1.75, 3.78] | <0.00001 | 82 |
| Low cardiac output | 5 | 2.30 [1.05, 5.004] | 0.04 | 95 |
| Congestive heart failure | 5 | 2.17 [0.96, 4.96] | 0.06 | 95 |
| Mortality | 6 | 0.19 [0.08, 0.30] | 0.0004 | 93 |