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. 2016 May 17;2016:4759040. doi: 10.1155/2016/4759040

Table 2.

Cut-off values and the discriminatory ability of five biomarkers by ROC curve analysis, which distinguishes IPF patients (n = 65) from control subjects (n = 132).

MMP-7 CCL18 KL-6 SP-A SP-D
AUC 0.9638 0.7036 0.9957 0.7865 0.9242
95% CI 0.9374–0.9901 0.6275–0.7815 0.9898–1.0020 0.7229–0.8501 0.8866–0.9619

Cut-off value 5.56 ng/mL 38.7 ng/mL 476 U/mL 44.0 ng/mL 107.0 ng/mL
Sensitivity 87.7% 66.2% 96.9% 66.2% 84.6%
Specificity 93.2% 67.4% 98.5% 76.5% 88.6%
Diagnostic accuracy 91.4% 67.0% 98.0% 73.1% 87.3%
Likelihood ratio 12.9 2.0 64.0 2.8 7.5

ROC: receiver operating characteristic, IPF: idiopathic pulmonary fibrosis, MMP-7: matrix metalloproteinase-7, CCL18: CC-chemokine ligand 18, KL-6: Krebs von den Lungen-6, SP-A: surfactant protein-A, SP-D: surfactant protein-D, AUC: area under the curve, and 95% CI: 95% confidence interval.

Control subjects consisted of 31 patients with bacterial pneumonia and 101 healthy controls.