Table 2.
MMP-7 | CCL18 | KL-6 | SP-A | SP-D | |
---|---|---|---|---|---|
AUC | 0.9638 | 0.7036 | 0.9957 | 0.7865 | 0.9242 |
95% CI | 0.9374–0.9901 | 0.6275–0.7815 | 0.9898–1.0020 | 0.7229–0.8501 | 0.8866–0.9619 |
| |||||
Cut-off value | 5.56 ng/mL | 38.7 ng/mL | 476 U/mL | 44.0 ng/mL | 107.0 ng/mL |
Sensitivity | 87.7% | 66.2% | 96.9% | 66.2% | 84.6% |
Specificity | 93.2% | 67.4% | 98.5% | 76.5% | 88.6% |
Diagnostic accuracy | 91.4% | 67.0% | 98.0% | 73.1% | 87.3% |
Likelihood ratio | 12.9 | 2.0 | 64.0 | 2.8 | 7.5 |
ROC: receiver operating characteristic, IPF: idiopathic pulmonary fibrosis, MMP-7: matrix metalloproteinase-7, CCL18: CC-chemokine ligand 18, KL-6: Krebs von den Lungen-6, SP-A: surfactant protein-A, SP-D: surfactant protein-D, AUC: area under the curve, and 95% CI: 95% confidence interval.
∗Control subjects consisted of 31 patients with bacterial pneumonia and 101 healthy controls.