Table 1.

The functional characterization of protein interaction networks in three clusters.

Cluster		GO:term	Term name	p value
Cluster 1	Biological processes	GO:0016568	Chromatin modification	7.9E − 21
		GO:0006325	Chromatin organization	1.3E − 20
		GO:0051568	Histone H3-K4 methylation	9.2E − 20
	Cellular components	GO:0034708	Methyltransferase complex	5.6E − 38
		GO:0035097	Histone methyltransferase complex	5.6E − 38
		GO:0044451	Nucleoplasm part	3.4E − 20
	Molecular functions	GO:0042054	Histone methyltransferase activity	2.5E − 20
		GO:0008170	N-Methyltransferase activity	5.6E − 19
		GO:0008276	Protein methyltransferase activity	5.6E − 19
Cluster 2	Biological processes	GO:0045944	Positive regulation of transcription from RNA polymerase II promoter	4.7E − 16
		GO:0006357	Regulation of transcription from RNA polymerase II promoter	4.6E − 15
		GO:0010628	Positive regulation of gene expression	9.5E − 15
	Cellular components	GO:0005634	Nucleus	3.4E − 9
		GO:0044451	Nucleoplasm part	6.2E − 9
		GO:0005667	Transcription factor complex	4.3E − 7
	Molecular functions	GO:0008134	Transcription factor binding	6.2E − 23
		GO:0016563	Transcription activator activity	1.6E − 18
		GO:0030528	Transcription regulator activity	9.6E − 16
Cluster 3	Biological processes	GO:0000082	G1/S transition of mitotic cell cycle	1.8E − 11
		GO:0007049	Cell cycle	9.7E − 10
		GO:0022402	Cell cycle process	5.1E − 9
	Cellular components	GO:0000307	Cyclin-dependent protein kinase holoenzyme complex	8.9E − 14
		GO:0005654	Nucleoplasm	4.3E − 10
		GO:0044428	Nuclear part	6.7E − 9
	Molecular functions	GO:0004693	Cyclin-dependent protein kinase activity	3.7E − 6
		GO:0016538	Cyclin-dependent protein kinase regulator activity	9.5E − 5
		GO:0030332	Cyclin binding	3.0E − 3