Table 2.
Incidence of EGFR-TKI-associated skin toxicity
| EGFR-TKIs | Study | Area | Rash |
Dry skin |
Pruritus |
Stomatitis |
Paronychia |
References | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| All (%) | ≥G3 (%) | All (%) | ≥G3 (%) | All (%) | ≥G3 (%) | All (%) | ≥G3 (%) | All (%) | ≥G3 (%) | ||||
| Gefitinib | NEJ002 | Japan | 71 | 5 | – | – | – | – | – | – | – | – | Maemondo et al. (37) |
| WJTOG3405 | Japan | 74 | 2 | 47 | 0 | – | – | 19 | 0 | 28 | 1 | Mitsudomi et al. (38) | |
| WJOG5108L | Japan | 75 | 2 | – | – | – | – | – | – | – | 1 | Katakami et al. (39) | |
| IPASS | Asia | 66 | 3 | 24 | 0 | 19 | 0.7 | 17 | 0.2 | 14 | 0.3 | Mok et al. (40) | |
| Erlotinib | DELTA | Japan | 93 | 13 | – | – | – | – | – | – | – | – | Kawaguchi et al. (41) |
| JO22903 | Japan | 83 | 14 | 77 | 1 | 64 | 3 | 63 | 1 | 67 | 1 | Goto et al. (42) | |
| JO25567 | Japan | 99 | 19 | 58 | 0 | 42 | 0 | 60 | 3 | 65 | 4 | Seto et al. (43) | |
| WJOG5108L | Japan | 92 | 18 | – | – | – | – | – | – | – | 4 | Katakami et al. (39) | |
| OPTIMAL | China | 73 | 2 | – | – | – | – | 13 | 1 | 4 | 0 | Zhou et al. (44) | |
| EURTAC | Europe | 80 | 13 | – | – | – | – | – | – | – | – | Rosell et al. (45) | |
| Afatinib | Lux-Lung 3 | Japan | 100 | 20 | 46 | 0 | 20 | 0 | 91 | 35 | 93a | 26a | Kato et al. (46) |
| Lux-Lung 3 | Global | 89 | 16 | 29 | 0.4 | 19 | 0.4 | 72 | 9 | 57 | 11 | Sequist et al. (47) | |
| Lux-Lung 6 | Asia | 81 | 15 | – | – | 11 | 0.4 | 52 | 5 | 33 | 0 | Wu et al. (48) | |
aThese events are described as ‘Nail events’ in the literature.