Table 5.

Strategy for the management of EGFR-TKI-associated paronychia

	Systemic	Topical
Prevention	No recommendation	Self-care (hand protection, cleanliness, nail trimming, cushioning) Keeping dry and avoid soaking water long time (if necessary, putting on washing-up gloves) Emollient Avoid irritant Avoid trauma/ injury Avoid restrictive shoes
Treatment	If infection is concomitant, apply systemic antibiotics (cephems or minocycline)	Mild Washing and cleanness Helical taping Topical steroid: very strong or strongest class Topical antibiotics Adapalene gel Moderate to severe Cryotherapy with liquid nitrogen or surgical resection for over-granulation Surgical intervention (partial nail avulsion)