Table 3.
Summary of the MCMC simulations of the marginal posterior distributions of pharmacokinetic parameters from the final model of dexmedetomidine
| Parameter, unit | Description | θ, Mean (90 % HDI) |
|---|---|---|
| θ CL, L/h 70 kg−1 | Total clearance | 41.6 (39.0–44.3) |
| θ Q, L/h 70 kg−1 | Distribution clearance | 56.8 (43.5–73.5) |
| θ V1, L 70 kg−1 | Volume of distribution of central compartment | 52.0 (43.2–59.6) |
| θ V2,L 70 kg−1 | Volume of distribution of peripheral compartment | 70.4 (63.0–79.8) |
| θ TE50, weeks | Age at which clearance is 50 % of adult value | 42.5 (61.7–47.8) |
| θ Hill | Slope of clearance maturation | 2.45 (1.72–3.39) |
| f CL | Fractional change of CL | 1.31(0.910–1.82) |
| f Q | Fractional change of Q | 1.02 (0.722–1.40) |
| f V1 | Fractional change of V1 | 1.50 (1.33–1.65) |
| f V2 | Fractional change of V2 | 0.86 (0.630–1.17) |
HDI highest density interval