Table 2.

Over‐represented pathways in ob/ob mouse model. Numbers are counts of differentially regulated genes in each pathway in the specified tissue

Pathway	Stomach	Duodenum	Jejunum	Ileum	A.colon	D.colon
(A) Pathways over‐represented in up‐regulated genes
Blood coagulation	15*	0	0	0	0	0
Bile acids regulation of glucose and lipid metabolism via FXR	10*	0	0	3#	0	0
Glycine, serine, cysteine and threonine metabolism	10*	0	0	0	0	0
Linoleic acid	6*	0	0	0	0	0
FXR‐dependent negative‐feedback regulation of bile acids concentration	6*	0	0	0	0	0
Platelet microparticle generation	14*	0	0	0	0	0
Phenylalanine metabolism	7*	0	0	0	0	0
PXR sigling via cross‐talk	6*	0	0	2#	0	0
Propiote metabolism p.1	5*	0	0	0	0	0
Leucine, isoleucine and valine metabolism.p.2	7*	0	0	0	0	0
Tight junctions	11*	0	0	0	0	0
(L)‐Alanine, (L)‐cysteine, and (L)‐methionine metabolism	6*	0	0	0	0	0
Sulfur metabolism	6*	0	0	0	0	0
FXR‐regulated cholesterol and bile acids cellular transport	6*	0	0	0	0	0
Triacylglycerol metabolism p.2	3#	3*	0	0	0	0
Glycolysis and gluconeogenesis p.1	0	0	0	4*	0	0
Fructose metabolism	5#	0	0	4*	0	0
GnRH sigling	0	0	0	6*	0	0
Aldosterone‐mediated regulation of EC sodium transport	0	0	0	2#	2#	3*
Impaired NO sigling in CF airways	0	0	0	0	0	2*
(B) Pathways over‐represented in down‐regulated genes
Huntingtin‐depended transcription deregulation in Huntington's Disease	5*	0	0	0	0	0
Antigen presentation by MHC class II	4*	0	0	0	0	0
IFN alpha/beta sigling pathway	0	0	0	0	0	4*
Antiviral actions of Interferons	4#	0	0	0	0	4*
IFN gamma sigling pathway	0	0	0	0	0	3

*indicates FDR < 0.1 and ^# P‐value < 0.05 for the significance of the pathway in the specified tissue.