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. 2016 May 24;4(10):e12814. doi: 10.14814/phy2.12814

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© 2016 The Authors. Physiological Reports published by Wiley Periodicals, Inc. on behalf of the American Physiological Society and The Physiological Society.

This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Divalent cations reduce conduction in the DCMD axon. (A) Relative CV profiles show decreased CV after 50 min of exposure to 10 mmol/L of cadmium at room temperature (RT). (B) Relative conduction velocity ratios show cadmium had a significant main effect, reducing velocity while removing extracellular calcium (Calcium Free) caused no changes (Controls: n = 9; Cadmium: n = 8; Calcium free: n = 5; Two‐way ANOVA with Holm–Sidak pairwise multiple comparisons, df = 2, F = 13.2, P < 0.001). (C) Relative CV profiles after 15 min exposure to cadmium at 35°C (HT). (D) Relative CV ratios show cadmium at 35°C had a significant main effect after 15 min (Control: n = 6; Cadmium: n = 7; Two‐Way ANOVA, df = 1, F = 108.0, P < 0.001). (E) Relative CV profiles after 20 min exposure to nickel at 35°C. (F) Relative CV ratios show nickel at 35°C had a significant main effect after 20 min (Control: n = 7; Nickel: n = 6; Two‐Way ANOVA, df = 1, F = 41.7, P < 0.001).