Figure 2. Plasma and CSF Aβ in different diagnostic groups.

Plasma (A–C, Simoa immunoassay) and CSF (D–F, Euroimmun immunoassay) levels of Aβ42, Aβ40 and the Aβ42/Aβ40 ratio in patients with SCD (n = 174), MCI (n = 214), AD (n = 57) and controls (n = 274). Data are presented as mean ± 95% confidence interval (CI); p values are from univariate general linear models controlling for age and gender; statistical significance was set to p < 0.008 (0.05/6) to account for Bonferroni correction. AD, Alzheimer’s disease; CSF, cerebrospinal fluid; SCD, subjective cognitive decline; MCI, mild cognitive impairment.