Table 3. Associations between plasma Aβ levels and composite amyloid PET SUVR.
All cases | Control | SCD | MCI | |
---|---|---|---|---|
Aβ42 | r = −0.162, p = 0.003−0.08 (−0.09, −0.07) | r = 0.005,p = 0.953 | r = −0.189,p = 0.056 | r = −0.295, p = 0.002−0.09 (−0.1, −0.06) |
Aβ40 | r = −0.012, p = 0.828 | r = 0.103,p = 0.251 | r = 0.014, p = 0.886 | r = −0.199, p = 0.035−0.006 (−0.009, −0.004) |
Aβ42/Aβ40 | r = −0.167, p = 0.002−18 (−27, −10) | r = −0.130,p = 0.148 | r = −0.205,p = 0.038−33 (−42, −25) | r = −0.154, p = 0.105 |
MCI, mild cognitive impairment; SCD, subjective cognitive decline; PET, positron emission tomography; SUVR, standardized uptake value ratio.
Plasma Aβ were measured using Simoa immunoassay. Associations between plasma Aβ and composite [18F]flutemetamol SUVR were first evaluated with Pearson’s correlation analysis and if significant correlations were found further investigated using RMA adjusting for age and gender. Data are presented as r, p from Pearson’s correlation analysis and slope estimates (95% CI) from RMA; significant results are shown in bold.