Table 1.
Baseline characteristics for the study population and by baseline osteoarthritis status
| Total population (n=51 386) |
Non-OA participants (n=30 977) |
OA participants (n=20 409) |
p Value | |
|---|---|---|---|---|
| Age (years), mean (SD) | 68.2 (8.6) | 67.5 (8.7) | 69.1 (8.6) | <0.0001 |
| BMI (kg/m2), mean (SD) | 26.9 (5.9) | 26.6 (5.7) | 27.4 (6.2) | <0.0001 |
| Current or past AOM, excluding oestrogen, n (%) |
13 817 (28) | 7427 (25) | 6390 (32) | <0.0001 |
| Current or past oestrogen or hormone replacement, n (%) |
21 929 (43) | 12 609 (41) | 9320 (46) | <0.0001 |
| Region, n (%) | <0.0001 | |||
| Canada/Australia | 6066 (12) | 3851 (12) | 2215 (11) | |
| Europe | 21 390 (42) | 10 890 (35) | 10 500 (51) | |
| USA | 23 931 (47) | 16 237 (52) | 7694 (38) | |
| Falls in past 12 months, n (%) |
<0.0001 | |||
| None | 31 881 (63) | 20 264 (66) | 11 617 (57) | |
| One | 11 567 (23) | 6781 (22) | 4786 (24) | |
| Two or more | 7453 (15) | 3609 (12) | 3844 (19) | |
| Comorbidities, n (%) | ||||
| Asthma | 5763 (11) | 3015 (9.8) | 2748 (14) | <0.0001 |
| Chronic bronchitis or emphysema |
4254 (8.4) | 2048 (6.7) | 2206 (11) | <0.0001 |
| Stroke | 1926 (3.8) | 1089 (3.5) | 837 (4.2) | <0.001 |
| Ulcerative colitis or Crohn’s disease |
964 (1.9) | 483 (1.6) | 481 (2.4) | <0.0001 |
| Parkinson’s disease | 258 (0.5) | 119 (0.4) | 139 (0.7) | <0.0001 |
| Multiple sclerosis | 312 (0.6) | 196 (0.6) | 116 (0.6) | 0.39 |
| Cancer | 7212 (14) | 4252 (14) | 2960 (15) | 0.007 |
| Diabetes | 1764 (3.5) | 1064 (3.5) | 700 (3.5) | 0.99 |
| Prior fracture, n (%) | 11 903 (23) | 6307 (20) | 5596 (27) | <0.0001 |
| Risk factors for fracture, n (%) |
||||
| Current cortisone use | 1342 (2.7) | 558 (1.8) | 784 (3.9) | <0.0001 |
| Secondary osteoporosis* | 10 031 (20) | 5784 (19) | 4247 (21) | <0.0001 |
| Alcohol >20 drinks/week | 253 (0.5) | 154 (0.5) | 99 (0.5) | 0.85 |
*
FRAX definition: use of anastrozole, exemestane, or letrozole; diagnosis of colitis, type I diabetes, or menopause before age 45 years.
AOM, antiosteoporosis medication; BMI, body mass index; OA, osteoarthritis; SD, standard deviation.