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. Author manuscript; available in PMC: 2016 May 31.
Published in final edited form as: Immunobiology. 2014 Aug 10;219(12):924–931. doi: 10.1016/j.imbio.2014.08.001

Figure 6. Schematic diagram of Hsp90-mediated Ag presentation. Endosomal pathway of Hsp90 chaperoned antigen presentation.

Figure 6

Hsp90-OVA peptide complexes are internalized by APC in an SREC-I receptor-mediated, Cdc42-regulated pinocytic pathway into the GEEC compartment, which is also regulated by the activity Src-tyrosine kinase. OVA peptides then traverse early endosomes complexed to Hsp90 and SREC-I and can be processed and loaded onto MHC-II molecules in recycling endosomes. MHC-II-OVA peptide complexes can then recycle to the plasma membrane and encounter CD4+ T cells. In an addition, MHCII and SREC-I appear to be closely associated in the cell. Both receptors are trafficked to plasma membrane from Golgi and endocytosed in the presence of Hsp90 complexed with Ova and this association may be involved in peptide loading onto MHCII.