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. 2016 May 30;213(6):913–920. doi: 10.1084/jem.20151990

Figure 2.

Figure 2.

CD4 and CD8 RTEs are less efficient than mature T cells at inducing diabetes. (A) 106 naive OT-I RTEs or MN T cells were transferred with 5–8 × 105 bulk naive OT-II Rag1−/− T cells into separate RIP-mOVA Tg hosts. (B) 7 × 105 to 106 naive OT-II RTEs or MN T cells were transferred with 2–3 × 106 bulk naive OT-I T cells into separate RIP-mOVA Tg hosts. Compiled host disease incidence is shown from three to five independent experiments. Parentheses indicate the number of diabetic mice over the total number of mice per group. ***, P ≤ 0.005, using a log-rank test. (C) 106 naive OT-II RTEs or MN T cells were cotransferred with 2 × 106 bulk naive OT-I T cells into RIP-mOVA Tg hosts. Proliferation (left) and cytokine production (right) by donor OT-I T cells from recipient pLNs was quantified 7 d later. Data are presented as mean ± SEM and are representative of two independent experiments (n = 6–8). **, P ≤ 0.01, using an unpaired Student’s t test.