Table 3.
Univariate analysis of risk factors for clinical postoperative recurrence in Crohn’s disease
| Median time to clinical POR (mo) | HR [95%CI] | P value | |
| Age | 1.00 [0.99-1.01] | 0.4 | |
| Age | |||
| < 35 yr | 45.2 | Reference | |
| ≥ 35 yr | 30.2 | 1.25 [0.84-1.85] | 0.27 |
| Age at diagnosis | |||
| ≤ 16 yr | 38.1 | Reference | |
| 16-40 yr | 48.0 | 0.81 [0.43-1.54] | 0.52 |
| ≥ 40 yr | 30.2 | 1.03 [0.48-2.23] | 0.93 |
| Tobacco use | |||
| Non-smoker | 45.2 | Reference | |
| Active smoker | 43.7 | 1.00 [0.66-1.53] | 0.98 |
| Previous intestinal resection | |||
| No | 51.0 | Reference | |
| Yes | 26.6 | 1.62 [1.07-2.44] | 0.02 |
| Total resection length > 50 cm | |||
| No | 38.1 | Reference | |
| Yes | 33.4 | 1.20 [0.66-2.16] | 0.55 |
| Disease behavior (Montreal classification) | |||
| B1 | 84.5 | Reference | |
| B2 | 54.5 | 1.39 [0.48-4.00] | 0.53 |
| B3 | 28.9 | 1.61 [0.56-4.56] | 0.37 |
| Fistulizing Crohn’s disease (B3) | |||
| No | 58.2 | Reference | |
| Yes | 28.9 | 1.21 [0.81-1.78] | 0.34 |
| Perianal lesions | |||
| No | 54.5 | Reference | |
| Yes | 26.9 | 1.26 [0.85-1.86] | 0.24 |
| Type of perianal lesions | |||
| Non-fistulizing lesions | 54.5 | Reference | |
| Fistula, abscess | 20.5 | 1.46 [1.01-2.16] | 0.05 |
| Disease duration | 1.00 [0.99-1.01] | 0.31 | |
| Ileal resection > 50 cm | |||
| No | 33.4 | Reference | |
| Yes | 59.5 | 0.72 [0.26-2.02] | 0.54 |
| Prior exposure to anti-TNF therapy before surgery | |||
| No | 48.0 | Reference | |
| Yes | 24.0 | 2.64 [1.24-4.33] | 0.007 |
| Thiopurines therapy in prevention of clinical postoperative recurrence | |||
| No | 44.8 | Reference | |
| Yes | 43.7 | 1.14 [0.74-1.76] | 0.53 |
| Anti-TNF therapy in prevention of clinical postoperative recurrence | |||
| No | 48.6 | Reference | |
| Yes | 29.3 | 1.39 [0.88-2.20] | 0.16 |
| Period of surgery | |||
| 1986-1999 | Reference | ||
| 2000-2015 | 1.71 [1.12-2.63] | 0.013 |
CRP: C-reactive protein; TNF: Tumor necrosis factor.