Table 1.
Mean (arithmetic) plasma pharmacokinetic parameters for fluralaner in dogs following single topical and i.v. administration
| Parameters | Topical | Topical | Topical | Intravenousb |
|---|---|---|---|---|
| 12.5 mg/kg | 25.0 mg/kg | 50.0 mg/kg | 12.5 mg/kg | |
| n = 6 | n = 6 | n = 6 | n = 6 | |
| Cmax (ng/mL) | 358 ± 94 | 727 ± 191 | 1698 ± 318 | 7109 ± 908 |
| tmax a (day) | 42 (range 21–63) | 25 (range 14–56) | 25 (range 7–42) | n/a |
| AUC(0→t) (day*ng/ml) | 18933 ± 3599 | 41243 ± 7467 | 85852 ± 17283 | 87198 ± 11835 |
| AUC(0→∞) (day*ng/ml) | 19577 ± 3982 | 43375c ± 8752 | 93468c ± 20424 | 87779 ± 12004 |
| t1/2 (day) | 17 ± 4 | 21c ± 3 | 17c ± 3 | 15 ± 2 |
| tlast (day) | 112 ± 0 | 112 ± 0 | 112 ± 0 | 109 ± 9 |
| MRT (day) | 47 ± 1 | 48c ± 4 | 43c ± 6 | 20 ± 3 |
| Cl (L/kg/day) | n/a | n/a | n/a | 0.14 ± 0.02 |
| Vz (L/kg) | n/a | n/a | n/a | 3.1 ± 0.5 |
| F (%) | 22 ± 4 | 24 ± 4 | 25 ± 5 | n/a |
aMedian, other values are mean ± standard deviation
bData previously published in Kilp et al. [4]; cMean consits of n = 4 (50.0 mg/kg)/ n = 5 (25.0 mg/kg) values; other values excluded as considered unreliable; see Methods
n/a - not applicable