Table 3.

Association between endothelial activation and inflammation scores and cognitive domains

		Endothelial activation		Inflammation
		B (95% CI)	P	B (95% CI)	P
Memory
Simple linear regression		−0.33 (−0.56 to −0.11)	0.004	−0.17 (−0.39 to 0.05)	0.124
Multiple linear regression	Model 1	−0.15 (−0.34 to 0.05)	0.145	−0.08 (−0.27 to 0.10)	0.369
	Model 2	−0.16 (−0.36 to 0.04)	0.124	−0.09 (−0.28 to 0.10)	0.339
	Model 3	−0.15 (−0.35 to 0.06)	0.159	−0.08 (−0.26 to 0.11)	0.395
Executive function
Simple linear regression		−0.41 (−0.63 to −0.19)	<0.001	−0.26 (−0.48 to −0.04)	0.020
Multiple linear regression	Model 1	−0.23 (−0.40 to −0.07)	0.008	−0.13 (−0.29 to 0.03)	0.104
	Model 2	−0.24 (−0.42 to −0.07)	0.008	−0.16 (−0.32 to 0.01)	0.071
	Model 3	−0.22 (−0.40 to −0.04)	0.015	−0.12 (−0.28 to 0.04)	0.137
Information processing speed
Simple linear regression		−0.43 (−0.69 to −0.16)	0.002	−0.22 (−0.48 to 0.04)	0.101
Multiple linear regression	Model 1	−0.21 (−0.40 to −0.02)	0.035	−0.08 (−0.25 to 0.10)	0.390
	Model 2	−0.20 (−0.39 to −0.01)	0.042	−0.09 (−0.27 to 0.09)	0.324
	Model 3	−0.19 (−0.39 to 0.01)	0.061	−0.06 (−0.24 to 0.12)	0.480

Abbreviations: B, unstandardized regression coefficient; CI, confidence interval.

Model 1: adjusted for age, sex, and DART score; Model 2: adjusted for age, sex, DART score, and vascular risk factors; Model 3: adjusted for age, sex, DART score, and MRI markers.