Fig. 2.

Results at small and large bladder volumes displayed on a standard brain at threshold P = 0.01. R, right side. Color bars show values of student’s t. Crosshairs mark the most significant peak in a significant cluster(P < 0.05, corrected at cluster level). A: With small volume and without global normalization, activity during infusion was less than during withdrawal in a right frontoparietal region (apparent deactivation). B: With small volume and with global normalization, activity during infusion was greater than during withdrawal (activation) in a left inferior temporal region and, as a trend, on the right and near the midbrain PAG. C: Results at large volume (strong desire to void) without global normalization. Activity during infusion was greater than during withdrawal in a right frontoparietal region and, less prominently, the dACC/SMA complex.