TABLE II.

Main Effects of Bladder Filling (Infusion) at Low and High Bladder Volumes, for the Contrast (Infusion Minus Withdrawal) With and Without Global Normalization, and for Comparisons of Infusion and Withdrawal With Baseline Activity

	Small bladder volume		Large bladder volume
Contrast	# Activated and deactivated voxels, sign of contrast (# of significant clusters), corrected P-value of most significant cluster	Location of peak in most significant cluster BA MNI coords	# Activated and deactivated voxels, sign of contrast (# of significant clusters), corrected P-value of most significant cluster	Location of peak in most significant cluster BA MNI coords
Infusion–withdrawal, no global normalization	Activated 0 Deactivated 49,327 −(1) P = 0.000	R parietal postcentral BA 40 −32, −34, 54	Activated 29 294 Deactivated 119 +(1) P = 0.000	R frontal precentral BA 4 −34, −18, 52
Infusion–withdrawal, with global normalization	Activated 11 198 Deactivated 4,912 +(1) P = 0.000	L temporal subgyral BA 21 −44, −12, −12	Activated 1,532 Deactivated 15,900 −(1) P = 0.000	L temporal middle BA 39 48, −74, 10
Withdrawal-baseline	Activated 49 116 Deactivated 975 +(1) P = 0.000	R frontal medial BA 6 6, −16, 70	Activated 4,335 Deactivated 589 (0)	n/a
Infusion-baseline	Activated 3,293 Deactivated 19,132 −(1) P = 0.000	R occipital precuneus BA 31 22, −60, 22	Activated 7,568 Deactivated 2,500 +(1) P = 0.03	L frontal precentral BA 4 −48, −6, 50

BA, Brodmann area. MNI coords, Montreal Neurological Institute coordinates.