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. 2016 May 31;6:26874. doi: 10.1038/srep26874

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Copyright © 2016, Macmillan Publishers Limited

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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During development, deleting RBP-Jκ from Ngn3 progenitors blocks Notch signaling but doesn’t push the cells towards the acinar fate since the Ptf1a/RBP-Jκ complex cannot form and promote the acinar differentiation pathways. Some of the Notch-deleted, Ngn3 progenitors fail to differentiate express high levels of Sox9 and form disorganized masses.