Figure 2. Detection of extracellular proteins in dystrophic muscle.

(a) List of significantly different extracellular proteins organized by increasing p-value (decreasing statistical significance). Red is increased abundance, green is decreased abundance compared to the average abundance across all data-points (both ages and both genotypes) for each protein. WT = wild type, Dys = dystrophic (mdx^4cv). (b) Mapping of differentially abundant extracellular proteins to Protein class using the functional annotation tool PANTHER (http://www.pantherdb.org/) reveals enrichment in enzyme modulators and signaling proteins, both classes including several serine protease inhibitors. (c) Mapping of differentially abundant extracellular proteins to Molecular function using the functional annotation tool PANTHER confirms the enrichment in serine protease inhibitors.