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. Author manuscript; available in PMC: 2017 May 22.
Published in final edited form as: J Mol Biol. 2016 Mar 22;428(10 Pt A):1986–2000. doi: 10.1016/j.jmb.2016.03.015

Figure 5. Structures of Elements of the Cytoplasmic Filaments.

Figure 5

The structures represented in panels (a) and (b) are the most complex assemblies of the CFs known so far. (a) The trimeric sc(Nup159-Dbp5-Gle1) complex (PDB 3RRM) is an important regulatory element for mRNA export [87]. (b) The sc(Nup159-Nup82-Nup116) complex (PDB 3PBP) likely represents the anchoring element for the CF to the main NPC scaffold [85], because of the additional contacts scNup116 and its paralogs scNup100 and scNup145N can form with other nups [31,32,50]. (c, d) Ran interacts at the NPC periphery, including CF and basket and predominantly in metazoa, with elements that recognize either Ran-GDP (PDB 3GJ3–8, 3CH5) or Ran-GTP (PDB 1RRP) [91–93]. All images are paired with a schematic representation of the interacting protein fragments, color-coded to match the cartoons.