Table 4.
In Vitro Antimicrobial Activities of 2, 5, 6, 7, and 8 (IC50 in µM)a
| antifungal | antibacterial | |||||
|---|---|---|---|---|---|---|
| compound |
C. albicans |
C. krusei |
MRSa |
S. aureus |
E. coli |
M. intracellulare |
| 2 | 60.5 | 60.5 | 24.4 | 29.6 | na | na |
| 5 | na | nt | 53.4 | na | na | na |
| 6 | na | 53.4 | 6.7 | 12.2 | na | na |
| 7 | 4.6 | nt | nt | nt | na | 30.6 |
| 8 | na | 54.0 | nt | 3.5 | 54.0 | na |
| amphotericin B | 0.3 | 0.7 | ||||
| ciprofloxacin | 0.4 | 0.4 | 0.0 | 1.5 | ||
a
IC50 = the test concentration that affords 50% inhibition of growth. MRSa = methicillin-resistant Staphylococcus aureus. na = not active. nt = not tested.