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In Vitro Antiprotozoal Activities of 1, 2, 5, and 6 (IC50 and IC90 in µM)a
| antileishmanial | antimalarial | |||
|---|---|---|---|---|
| L. donovani | P. falciparum | |||
| compound | IC50 | IC90 | D6 | W2 |
| 1 | 40.3 | 91.3 | 7.2 | 4.0 |
| 2 | 57.5 | 96.8 | na | na |
| 5 | 10.7 | 18.7 | 7.2 | 6.7 |
| 6 | 42.7 | 85.4 | na | na |
| pentamidine | 3.8 | 19.1 | ||
| chloroquine | 0.1 | 0.5 | ||
IC50 = the test concentration that kills 50% cells compared to the solvent controls. IC90 = the test concentration that kills 90% cells compared to the solvent controls.
