Table 2.
Proportion of animals with Th1(+) or Th17(+) responses to MBP or OVA (response >75th percentile seen in non-infected animals treated with the same antibiotic).
| ceftiofur | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| infection: | spleen | infarcted brain | non-infarcted brain | |||||||||
| no | SA | PA | P | no | SA | PA | P | no | SA | PA | P | |
| Th1 MBP | 5/22 (23%) | 6/25 (24%) | 10/33 (30%) | NS | 3/13 (23%) | 6/25 (24%) | 8/33 (24%) | NS | 3/13 (23%) | 7/25 (28%) | 9/33 (27%) | NS |
| Th1 OVA | 5/22 (23%) | 8/25 (32%) | 11/33 (33%) | NS | 3/13 (23%) | 10/24 (42%) | 12/33 (36%) | NS | 3/13 (23%) | 3/25 (12%) | 4/33 (12%) | NS |
| Th17 MBP | 5/22 (23%) | 6/25 (24%) | 5/33 (15%) | NS | 3/13 (23%) | 3/25 (12%) | 2/33 (6%) | NS | 3/13 (23%) | 0/25 | 0/33 | 0.004 |
| Th17 OVA | 5/22 (23%) | 2/25 (8%) | 8/33 (24%) | NS | 3/13 (23%) | 3/23 (13%) | 1/33 (3%) | NS | 3/13 (23%) | 4/25 (16%) | 5/33 (15%) | NS |
| enrofloxacin | ||||||||||||
| infection: | spleen | infarcted brain | non-infarcted brain | |||||||||
| no | SA | PA | P | no | SA | PA | P | no | SA | PA | P | |
| Th1 MBP | 6/25 (24%) | 3/20 (15%) | 1/22 (4%) | NS | 6/20 (30%) | 3/20 (15%) | 13/22 (59%) | 0.008 | 5/19 (16%) | 11/20 (55%) | 14/22 (64%) | 0.04 |
| Th1 OVA | 5/24 (21%) | 5/20 (25%) | 4/22 (18%) | NS | 4/18 (22%) | 5/15 (33%) | 8/22 (36%) | NS | 4/17 (24%) | 9/17 (53%) | 13/22 (59%) | 0.06 |
| Th17 MBP | 6/25 (24%) | 2/20 (10%) | 1/22 (4%) | NS | 5/20 (25%) | 5/20 (25%) | 10/22 (45%) | NS | 5/19 (26%) | 4/20 (20%) | 7/22 (32%) | NS |
| Th17 OVA | 5/25 (20%) | 4/20 (20%) | 4/22 (18%) | NS | 4/18 (22%) | 3/15 (20%) | 10/22 (45%) | NS | 4/17 (24%) | 4/16 (25%) | 6/22 (27%) | NS |
MBP=myelin basic protein, OVA=ovalbumin, SA=Staphylococcus aureus, PA=Pseudomonas aeruginosa, NS=not significant (P≥0.10)