Figure 4.

The ability to produce the sequential spikes on the GABAergic neurons of the prelimbic cortices decreases in depression-like mice. The sequential spikes induced by various stimulus intensities were recorded on the GABAergic neurons in cortical slices under current-clamp. (A) Depolarization induced the sequential spikes on the GABAergic neurons in depression-like (red trace) and control mice (blue trace). (B) Spikes per second vs normalized stimuli in GABAergic neurons from the depression-like mice (red circles, n = 16 neurons) and the controls (blue squares, n = 15 neurons). *P  < .05. Arrow indicates spikes vs stimulus intensity taken for A.