Figure 5.

The frequency of excitatory synaptic transmission is upregulated in GABAergic neurons of the prelimbic cortex from depression-like mice. Spontaneous excitatory postsynaptic currents (sEPSCs) were recorded under voltage-clamp from control and depression-like mice in the presence of 10 μM bicuculline. (A) Left panels illustrate sEPSCs from control mice (blue traces) and right panels show sEPSCs from depression-like mice (reds). Calibration bars are 20 pA as well as 2 seconds (top traces) and 90ms (bottoms). (B) Cumulative probability vs sEPSC amplitudes from the depression-like mice (red circles) and control (blue squares). Dashed lines indicate sEPSC amplitudes at cumulative probability to 67% (CP₆₇) in the control (blue line; n = 9) and depression-like mice (red; n = 11, P  = .69). (C) Cumulative probability vs inter-sEPSC intervals from depression-like (red circles) and control mice (blue squares). Dashed lines are inter-sEPSC intervals at the cumulative probability to 67% (CP₆₇) in the control (blue line; n = 9) and depression-like mice (red; n = 11, P  < .001).