Figure 8.

The ability to fire the sequential spikes on the glutamatergic neurons of the prelimbic cortices does not change in depression-like mice. The sequential spikes induced by various stimulus intensities were recorded on GABAergic neurons in cortical slices under current-clamp. (A) Depolarization-induced sequential spikes on glutamatergic neurons from control (blue trace) and depression-like mice (red trace). (B) Spikes per second vs normalized stimuli in glutamatergic neurons from depression-like mice (red circles, n = 28 neurons) and controls (blue squares, n = 37 neurons). Arrow indicates spikes vs stimulus intensity taken for panel A.