Table 1. Individual effects of CMV and gender on the absolute numbers of different leukocyte subsets.
| CMV− | CMV+ | Male | Female | |
|---|---|---|---|---|
| Demographic factors | ||||
| No. (%) | 127 (50.8) | 123 (49.2) | 140 (54.9) | 115 (45.1) |
| Mean age in years (range) | 57.6 (50–65) | 57.8 (50–65) | 57.8 (50–65) | 57.5 (50–65) |
| Mean BMI (range) | 25.7 (19–39) | 26.0 (18–36) | 25.8 (19–35) | 25.9 (18–39) |
| Leukocyte subsets (cells/μl blood) | ||||
| Granulocytes | 2275 [2075–2495] | 2198 [2018–2394] | 2249 [2060–2457] | 2240 [2041–2459] |
| Monocytes | 198.5 [182.6–215.8] | 182.5 [168.8–197.3] | 192.8 [178.0–208.8] | 188.5 [173.0–205.5] |
| NK cells | 143.5 [126.0–163.3] | 118.2 [103.0–135.6]* | 131.6 [115.7–149.8] | 131.3 [114.3–150.9] |
| Lymphocytes | 2179 [2039–2329] | 2174 [2030–2328] | 1937 [1799–2087] | 2367 [2204–2541]**** |
| T cells | 1548 [1428–1678] | 1428 [1293–1577] | 1317 [1201–1445] | 1732 [1599–1875]**** |
| γδ T cells | 18.7 [16.01–21.85] | 17.4 [14.95–20.17] | 16.2 [14.0–18.8] | 20.6 [17.6–24.1]* |
| CD4/CD8 ratio | 3.3 [3.0–3.6] | 2.5 [2.3–2.7]**** | 2.7 [2.5–2.9] | 3.1 [2.8–3.3] |
| CD8 T cells | 331.7 [299.2–367.8] | 368.0 [328.4–412.3]* | 317.8 [285.0–354.3] | 393.8 [354.9–437.0]* |
| CD8 naive | 74.0 [63.3–86.4] | 64.7 [53.4–78.4] | 51.3 [43.2–61.0] | 100.9 [87.2–116.8]**** |
| CD8 CM | 13.8 [11.7–16.2] | 10.0 [8.5–11.7]* | 11.1 [9.3–13.1] | 13.0 [11.2–15.1] |
| CD8 TemRO | 142.4 [126.8–160.0] | 151.3 [134.7–169.9] | 144.6 [128.7–162.5] | 151.9 [135.5–170.2] |
| CD8 TemRA | 63.2 [54.9–72.9] | 102.3 [87.8–119.2]**** | 72.3 [62.5–83.7] | 88.9 [75.9–104.0] |
| CD4 T cells | 1084 [994.5–1181] | 911.3 [817.0–1016] | 852.0 [769.4–943.3] | 1205 [1109–1309]**** |
| CD4 naive | 414.0 [363.6–471.4] | 310.3 [265.5–362.7]* | 290.6 [251.1–336.3] | 460.2 [405.3–522.5]**** |
| CD4 CM | 262.1 [234.8–292.6] | 206.7 [182.9–233.5]* | 213.8 [188.4–242.7] | 260.5 [235.3–288.4]* |
| CD4 TemRO | 202.2 [184.0–222.2] | 206.3 [182.7–232.8] | 181.2 [162.9–201.5] | 239.5 [216.4–265.1]*** |
| CD4 TemRA | 38.1 [32.8–44.3] | 44.5 [37.8–52.3] | 32.2 [28.0–37.0] | 53.9 [45.9–63.3]**** |
| TFH cells | 214.3 [189.4–242.5] | 205.3 [178.9–235.6] | 186.4 [162.7–213.5] | 241.7 [215.9–270.6]* |
| Treg cells | 107.3 [97.5–118.1] | 90.7 [80.4–102.4] | 89.0 [79.7–99.4] | 113.6 [102.4–126.0]*** |
| naive Treg | 12.6 [10.7–14.7] | 11.08 [9.5–13.0] | 9.9 [8.4–11.5] | 14.7 [12.7–17.0]*** |
| memory Treg | 4.7 [4.0–5.6] | 3.2 [2.7–3.8]** | 3.9 [3.2–4.7] | 4.0 [3.4–4.7] |
| CD4+CD45RA+CD25dim | 27.0 [23.1–31.5] | 21.7 [18.3–25.6] | 20.3 [17.3–23.9] | 29.7 [25.5–34.4]*** |
| B cells | 286.7 [257.8–318.9] | 265.8 [241.0–293.0] | 259.2 [234.4–286.5] | 301.8 [271.8–335.0]* |
| transitional | 9.5 [8.1–11.2] | 7.7 [6.5–9.1] | 7.9 [6.8–9.1] | 9.7 [8.1–11.5] |
| naive mature | 175.3 [154.2–199.2] | 162.2 [142.1–185.1] | 160.9 [144.2–179.4] | 183.2 [161.6–207.7] |
| natural effector | 22.1 [18.4–26.6] | 26.6 [22.3–31.8] | 21.7 [18.7–25.2] | 23.8 [20.0–28.5] |
| CD27− memory | 15.5 [13.1–18.3] | 15.3 [13.4–17.6] | 14.8 [12.8–17.0] | 19.2 [16.8–22.0]** |
| CD27+ memory | 32.8 [28.1–38.3] | 36.6 [32.1–41.8] | 29.0 [25.5–33.0] | 36.7 [32.0–42.1]** |
Geometric mean of cells/μl blood [95% CI]. CMV− and CMV+ persons were compared, as well as males and females. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001. Bold numbers indicate significant differences within one subset. After a multiple testing correction only values with p < 0.0014 are considered significant. Significant differences after correction for multiple testing are underlined.