TABLE 4.
Drug susceptibility assessment in the fluorescent neuraminidase inhibition assay
| Virus name | NA subtype | Parameter |
Mean IC50 ± SD (nM)a |
|||||
|---|---|---|---|---|---|---|---|---|
| kcat ± SD (s−1) | Km ± SD (μM) | kcat/Km (M−1 s−1) | Oseltamivir carboxylate | Zanamivir | Peramivir | Laninamivir | ||
| A/American green-winged teal/Washington/195750/2014 | N1 | 134,254 ± 2,841 | 5.08 ± 0.41 | 3.29 × 1011 | 3.45 ± 0.35 | 0.33 ± 0.10 | 0.10 ± 0.03 | 0.19 ± 0.02 |
| A/northern pintail/Washington/40964/2014 | N2 | 115,191 ± 2,523 | 5.48 ± 0.45 | 2.56 × 1011 | 0.18 ± 0.06 | 0.75 ± 0.22 | 0.20 ± 0.03 | 1.05 ± 0.10 |
| A/Sichuan/26221/2014 | N6 | 147,235 ± 3,693 | 7.00 ± 0.63 | 2.36 × 1011 | 0.98 ± 0.18 | 0.98 ± 0.18 | 0.21 ± 0.03 | 1.95 ± 0.24 |
| A/gyrfalcon/Washington/41088-6/2014 | N8 | 173,671 ± 3,018 | 5.98 ± 0.38 | 4.55 × 1011 | 0.99 ± 0.20 | 0.35 ± 0.12 | 0.06 ± 0.02 | 0.22 ± 0.01 |
a
From the results of three independent experiments run in triplicate.