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. 2016 May 27;90(12):5611–5621. doi: 10.1128/JVI.00411-16

FIG 5.

FIG 5

HPV-16E7_H73E reverses pAKT attenuation mediated by HPV-16. (A) NIKS cells transfected with the HPV-16 genome or HPV-16 E7_H73E genome were plated and harvested as described for Fig. 1A. Samples were normalized to actin and the highest value. Statistics were calculated from three independent experiments (*, P < 0.05). (B) HPV-16 E7_H73E NIKS degrade p53 and unphosphorylated Rb to the same extent as HPV-16 NIKS. NIKS cells transfected with the HPV-16 genome or HPV-16 E7_H73E genome were plated and harvested as described for Fig. 1A. Samples were normalized to actin and the highest value. Statistics were calculated from five independent experiments (*, P < 0.05; **, P < 0.01).