TABLE 1.
Detailed characterization of the SIV-infected macaques used in the studyc
| Animal identifier | Duration of infection (days) | CNS score | Cell count (no. of cells/μl blood) |
Viral load(no. of SIV copies/ml) in: |
Tissue viral load (no. of SIV copies/μg tissue RNA) |
|||||
|---|---|---|---|---|---|---|---|---|---|---|
| CD4+ T cells | Monocytes | Plasma | CSF | Parietal cortex | Basal ganglion | Lung | Spleen | |||
| Pm1 | 62 | Severe | 166 | 1,271 | 6.50E+07 | 9.85E+06 | 5.65E+06 | 4.10E+06 | 74,024 | 2.59E+06 |
| Pm2 | 60 | Severe | 57 | 45 | 8.83E+07 | 2.43E+07 | 1.30E+06 | 1.11E+06 | 99,416 | 675,000 |
| Pm3 | 50 | Severe | 113 | 1,022 | 4.24E+07 | 4.98E+06 | 826,254 | 1.55E+06 | 503,785 | 1.22E+06 |
| Pm4 | 84 | Severe | 52 | 4,333 | 1.49E+09 | 1.14E+07 | 4.63E+06 | 1.92E+06 | 1,543 | 1.61E+07 |
| Pm5 | 86 | Mild | 222 | 493 | 1.18E+07 | 1.84E+07 | 1.48E+06 | 807,774 | 247 | 1.19E+07 |
| Pm6 | 85 | None | 396 | 525 | 3.65E+08 | 166,022 | 699 | 10,632 | 1,197 | 8.45E+06 |
| Pm7 | 83 | None | 418 | 767 | 1.05E+07 | 117,088 | 22 | 14,995 | 332 | 8.68E+06 |
| Pm8 | 79 | None | 56 | 416 | 2.20E+06 | 129,536 | ND | ND | 129 | 5.51E+06 |
| Pm9 | 87 | None | 464 | 874 | 1.25E+06 | 112,867 | ND | ND | 152 | 4.40E+06 |
| Pm10 | 84 | None | 693 | 1,071 | 300,229 | 12,105 | ND | ND | 1,797 | 204,000 |
| Pm11a | 84 | None | 119 | 612 | 651,191 | 142,755 | 196 | ND | 282 | 268,000 |
| Pm12b | 34 | None | 681 | 481 | 4.55E+08 | 20,761 | ND | ND | 741 | 866,000 |
| Pm13b | 35 | None | 390 | 350 | 1.72E+08 | 8.41E+07 | 3,365 | 96,705 | 421 | 1.62E+06 |
| Pm14b | 36 | None | 758 | 588 | 8.37E+07 | 1.33E+06 | 1,364 | 586 | 253 | 377,000 |
a
The animal was treated with fluconazole and paroxetine at day 12 postinoculation.
b
The animal was pretreated with minocycline at 28 days prior to infection.
c
The treatments did not affect virus replication or progression of disease. Abbreviations: ND, not detected (the level was below the limit of detection); Pm, pigtailed macaque.