TABLE 1.
Detailed characterization of the SIV-infected macaques used in the studyc
Animal identifier | Duration of infection (days) | CNS score | Cell count (no. of cells/μl blood) |
Viral load(no. of SIV copies/ml) in: |
Tissue viral load (no. of SIV copies/μg tissue RNA) |
|||||
---|---|---|---|---|---|---|---|---|---|---|
CD4+ T cells | Monocytes | Plasma | CSF | Parietal cortex | Basal ganglion | Lung | Spleen | |||
Pm1 | 62 | Severe | 166 | 1,271 | 6.50E+07 | 9.85E+06 | 5.65E+06 | 4.10E+06 | 74,024 | 2.59E+06 |
Pm2 | 60 | Severe | 57 | 45 | 8.83E+07 | 2.43E+07 | 1.30E+06 | 1.11E+06 | 99,416 | 675,000 |
Pm3 | 50 | Severe | 113 | 1,022 | 4.24E+07 | 4.98E+06 | 826,254 | 1.55E+06 | 503,785 | 1.22E+06 |
Pm4 | 84 | Severe | 52 | 4,333 | 1.49E+09 | 1.14E+07 | 4.63E+06 | 1.92E+06 | 1,543 | 1.61E+07 |
Pm5 | 86 | Mild | 222 | 493 | 1.18E+07 | 1.84E+07 | 1.48E+06 | 807,774 | 247 | 1.19E+07 |
Pm6 | 85 | None | 396 | 525 | 3.65E+08 | 166,022 | 699 | 10,632 | 1,197 | 8.45E+06 |
Pm7 | 83 | None | 418 | 767 | 1.05E+07 | 117,088 | 22 | 14,995 | 332 | 8.68E+06 |
Pm8 | 79 | None | 56 | 416 | 2.20E+06 | 129,536 | ND | ND | 129 | 5.51E+06 |
Pm9 | 87 | None | 464 | 874 | 1.25E+06 | 112,867 | ND | ND | 152 | 4.40E+06 |
Pm10 | 84 | None | 693 | 1,071 | 300,229 | 12,105 | ND | ND | 1,797 | 204,000 |
Pm11a | 84 | None | 119 | 612 | 651,191 | 142,755 | 196 | ND | 282 | 268,000 |
Pm12b | 34 | None | 681 | 481 | 4.55E+08 | 20,761 | ND | ND | 741 | 866,000 |
Pm13b | 35 | None | 390 | 350 | 1.72E+08 | 8.41E+07 | 3,365 | 96,705 | 421 | 1.62E+06 |
Pm14b | 36 | None | 758 | 588 | 8.37E+07 | 1.33E+06 | 1,364 | 586 | 253 | 377,000 |
The animal was treated with fluconazole and paroxetine at day 12 postinoculation.
The animal was pretreated with minocycline at 28 days prior to infection.
The treatments did not affect virus replication or progression of disease. Abbreviations: ND, not detected (the level was below the limit of detection); Pm, pigtailed macaque.