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. 2016 May 27;90(12):5643–5656. doi: 10.1128/JVI.00290-16

TABLE 1.

Detailed characterization of the SIV-infected macaques used in the studyc

Animal identifier Duration of infection (days) CNS score Cell count (no. of cells/μl blood)
Viral load(no. of SIV copies/ml) in:
Tissue viral load (no. of SIV copies/μg tissue RNA)
CD4+ T cells Monocytes Plasma CSF Parietal cortex Basal ganglion Lung Spleen
Pm1 62 Severe 166 1,271 6.50E+07 9.85E+06 5.65E+06 4.10E+06 74,024 2.59E+06
Pm2 60 Severe 57 45 8.83E+07 2.43E+07 1.30E+06 1.11E+06 99,416 675,000
Pm3 50 Severe 113 1,022 4.24E+07 4.98E+06 826,254 1.55E+06 503,785 1.22E+06
Pm4 84 Severe 52 4,333 1.49E+09 1.14E+07 4.63E+06 1.92E+06 1,543 1.61E+07
Pm5 86 Mild 222 493 1.18E+07 1.84E+07 1.48E+06 807,774 247 1.19E+07
Pm6 85 None 396 525 3.65E+08 166,022 699 10,632 1,197 8.45E+06
Pm7 83 None 418 767 1.05E+07 117,088 22 14,995 332 8.68E+06
Pm8 79 None 56 416 2.20E+06 129,536 ND ND 129 5.51E+06
Pm9 87 None 464 874 1.25E+06 112,867 ND ND 152 4.40E+06
Pm10 84 None 693 1,071 300,229 12,105 ND ND 1,797 204,000
Pm11a 84 None 119 612 651,191 142,755 196 ND 282 268,000
Pm12b 34 None 681 481 4.55E+08 20,761 ND ND 741 866,000
Pm13b 35 None 390 350 1.72E+08 8.41E+07 3,365 96,705 421 1.62E+06
Pm14b 36 None 758 588 8.37E+07 1.33E+06 1,364 586 253 377,000
a

The animal was treated with fluconazole and paroxetine at day 12 postinoculation.

b

The animal was pretreated with minocycline at 28 days prior to infection.

c

The treatments did not affect virus replication or progression of disease. Abbreviations: ND, not detected (the level was below the limit of detection); Pm, pigtailed macaque.

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