FIG 10.

Positions of the key residues in the immature and mature hexamers. Key residues D87 (blue), E99 (red), K107 (yellow), A134 (green), and R145 (black) are marked with spheres. The CA dimer in the immature lattice is enlarged in the boxes in panel A. Residues 87 and 134 reside at the NTD dimer interface in the immature lattice (A), while none of the key residues forms any intermolecular interaction in the mature CA lattice of Cardone et al. (20) (B). Only the NTD and CTD are shown. The intermolecular contacts that are featured in Fig. 7D do not exist in mature virus and are not shown here.