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Retubulation of failing cardiomyocytes after rescue by AAV9.SERCA2a gene therapy.
A-C. Paired high resolution simultaneous surface HPICM (left) and confocal (right) images using SSCM technique from the surface of cardiomyocytes isolated from healthy (A), failing (B) and failing + AAV9SERCA2a (C), demonstrating recovery of T-tubule openings. D. Quantification of T-tubule density, corrected to healthy baseline (mean±SEM; n=14 myocytes per study arm). *p<0.05, **p<0.01.
