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. Author manuscript; available in PMC: 2016 Oct 21.
Published in final edited form as: Nature. 2016 Apr 13;532(7599):375–379. doi: 10.1038/nature17407

Figure 2. Chronic inhibition of magnesium transport leads to increased [Mg2+]i and long circadian period.

Figure 2

Chronic inhibition of magnesium transport by CHA or quinidine increases [Mg2+]i (a,b) and increases circadian period (c-f), traces and period dose-response of the CCA1-LUC (Ostreococcus) or Per2:luc (U2OS cells) reporters are shown. All plots are mean±SEM, with replicate numbers (n) indicated, p-values report significance by 1-way ANOVA and post-test for linear trend.