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. Author manuscript; available in PMC: 2016 Oct 21.
Published in final edited form as: Nature. 2016 Apr 13;532(7599):375–379. doi: 10.1038/nature17407

Figure 3. Reduced [Mg2+]i affects properties of cellular timekeeping and leads to an increase in ATP.

Figure 3

Bioluminescence traces showing reduced extracellular magnesium significantly affects amplitude and period length of circadian reporters in algal (a) and human cells (c). Low extracellular magnesium leads to decreased [Mg2+]i and increased [ATP]i in both cell types (b,d), measured after 4 days. All plots show mean±SEM, with replicate numbers (n) indicated, p-values (****p<0.0001, **p=0.01, *p=0.04) report significance by 1-way ANOVA (Ostreococcus) or t-test (U2OS).