Table 1. Overview of DNA repair pathways.
Repair system | Type of lesions | Accuracy |
---|---|---|
Base Excision Repair (BER) | Oxidative lesions | error free |
Nucleotide Excision Repair (NER) | Helix-distorting lesions | error free |
Translesion synthesis | Various lesions | error prone |
Miss Match Repair (MMR) | Replication errors | error free |
Single Stand Break Repair (SSBR) | Single strand breaks | error free |
Homologous Recombination (HR) | Double-strand breaks | mostly error free |
Non-Homologous End Joining (NHEJ) | Double-strand breaks | mostly error prone |
DNA Interstrand Crosslink Repair Pathway | Interstrand crosslinks | largely error free |