Extended Data Table 1. Template structures used for homology modeling or selected human crystal structures.
| Nucleoporin | AA covered by the model | Modeling template or human structure | Organism* | PDB Identifier | Model confidence† |
|---|---|---|---|---|---|
| Nup 107 | NTD (150-602) | Nup84/Nup145C/Sec13 | S.c. | 3IKO chain C | medium |
| CTD (667-924) | Crystal structure Nup107/Nup133 | H.s. | 3I4R chain A | high | |
| Nup133 | NTD (75-477) | Nup133 | H.s. | 1XKS | high |
| CTD (518-543) | Crystal structure Nup 107/Nup133 | H.s. | 3I4R chain B | high | |
| Nup96 | 277-751 | Nup84/Nup 145C/Sec13 | S.c. | 3IKO chain B | medium |
| Sec13 | 14-304 | Sec13Nup145C | H.s. | 3BG1 chain A | high |
| Nup85 | NTD (9-475) | Nup85 | S.c. | 3F3F chain C | medium |
| CTD (476-641) | Nic96 | S.c. | 2QX5 chain A | low | |
| Seh1 | 1-322 | Seh1 | S.c. | 3F3F chain A | high |
| Nup37 | 9-326 | Nup37 | S.p. | 4GQ2 chain P | medium |
| Nup160 | 41-1201 | Nup120 | S.p. | 4GQ2 chain M, 4FHN chain B | medium |
| Nup43 | 4-380 | Crystal structure | H.s. | 4179 chain A | high |
| Elys | NTD (3-493) | Elys | M.m. | 410O chain A | high |
| Nup93 | CTD (173-815) | Nic96 | S.c. | 2RFO chain A | medium |
| Nup188 | NTD (1-939) | Nup188 | M.t. | 4KF7 chain A | medium |
| Nup205 | NTD (9-1008) | Nup192 | S.c. | 4IFQ chain A | medium |
| Nup188 | M.t. | 4KF7 chain A | |||
| Nup155 | NTD (20-863) | Nup157 | S.c. | 4MHC chain A | high |
| CTD (871-1375) | Nup170 | S.c. | 315P chain A | high |
*
Organism: H.s. - Homo sapiens, M.m. - Mus musculus, S.c. - Saccharomyces cerevisiae, S.p. - Saccharomyces pombe, M.t. - Myceliophthora thermophila.
†
Model confidence was assessed as follows: high - human crystal structures or models based on very similar templates; medium - good quality models with confident overall sequence alignment but containing less confident regions; low - models expected to have correct fold but built based on low confidence sequence alignment.