Table 2.
Discovery analysis twin data (no CKD)
| Gene (CHR) | SNP | Locationa | A1 | MAF | BETA | P |
|---|---|---|---|---|---|---|
| ABCG2 (4) | rs2231146 | Intronic | C | 0.015 | −0.681 | 0.029 |
| ABCG2 (4) | rs12641369 | Intronic | A | 0.056 | −0.276 | 0.098 |
| ABCG2 (4) | rs2231137 | Missense | T | 0.056 | −0.276 | 0.098 |
| SLC2A9 (4) | rs4481233 | Intronic | T | 0.199 | −0.447 | 7.01E-06 |
| SLC2A9 (4) | rs13111638 | Intronic | T | 0.2 | −0.414 | 2.16E-05 |
| SLC2A9 (4) | rs6449213 | Intronic | C | 0.2 | −0.414 | 2.16E-05 |
| ABCC2 (10) | rs10509739 | 3′ downstream | T | 0.067 | −0.296 | 0.060 |
| ABCC2 (10) | rs4148396 | Intronic | T | 0.361 | −0.112 | 0.154 |
| ABCC2 (10) | rs2756111 | Intronic | C | 0.058 | 0.227 | 0.160 |
| SLC17A1-17A3 (6) | rs11969868 | Intronic | G | 0.183 | −0.241 | 0.014 |
| SLC17A1-17A3 (6) | rs9461211 | 5′ upstream | A | 0.452 | 0.163 | 0.028 |
| SLC17A1-17A3 (6) | rs2275906 | Synonymous | G | 0.131 | −0.247 | 0.032 |
| SLC22A10 (11) | rs7942667 | Intronic | C | 0.029 | 0.345 | 0.139 |
| SLC22A10 (11) | rs17158018 | Intronic | G | 0.029 | 0.345 | 0.140 |
| SLC22A10 (11) | rs17158022 | Intronic | A | 0.029 | 0.342 | 0.146 |
| SLC22A8 (11) | rs10792369 | 5′ upstream | C | 0.349 | 0.114 | 0.171 |
| SLC22A8 (11) | rs4149181 | Intronic | G | 0.082 | 0.167 | 0.213 |
| SLC22A8 (11) | rs4963326 | Intronic | A | 0.42 | 0.1 | 0.259 |
| SLC22A11 (11) | rs3759053 | 5′ upstream | C | 0.474 | 0.181 | 0.016 |
| SLC22A11 (11) | rs11231813 | 5′ upstream | G | 0.494 | −0.149 | 0.0496 |
| SLC22A11 (11) | rs17300741 | Intronic | T | 0.488 | −0.025 | 0.099 |
| ABCC4 (13) | rs4148499 | Intronic | T | 0.156 | −0.216 | 0.049 |
| ABCC4 (13) | rs12870204 | Intronic | T | 0.39 | −0.135 | 0.087 |
| ABCC4 (13) | rs9524848 | Intronic | G | 0.974 | −0.397 | 0.087 |
| SLC22A13 (3) | rs3805040 | Intronic | G | 0.054 | −0.23 | 0.188 |
| SLC22A13 (3) | rs1979845 | Intronic | T | 0.114 | −0.149 | 0.224 |
| SLC22A13 (3) | rs2236631 | Intronic | T | 0.053 | −0.147 | 0.374 |
| SLC22A6 (11) | rs11828074 | 5′ upstream | T | 0.063 | 0.145 | 0.339 |
| SLC22A6 (11) | rs11568621 | Intronic | A | 0.063 | 0.145 | 0.339 |
| SLC22A6 (11) | rs11568628 | Synonymous | T | 0.373 | 0.031 | 0.691 |
| SLC22A12 (11) | rs476037 | 3′-UTR | A | 0.136 | 0.166 | 0.143 |
| SLC22A12 (11) | rs578829 | 5′ upstream | C | 0.334 | 0.025 | 0.759 |
| SLC22A12 (11) | rs11231825 | Synonymous | T | 0.334 | 0.025 | 0.759 |
CKD, chronic kidney disease; SNP, single nucleotide polymorphism; CHR, chromosome; A1, minor allele; MAF, minor allele frequency; BETA, beta-coefficient from PLINK regression; P, P-value for beta-coefficient; UTR, untranslated region.
aSNP location from dbSNP.