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Enzyme expression does not affect virus replication and production. (a) A549 cells were infected separately with each EnAd virus to assess genome production ensuring all viruses were replicating efficiently. (b) Purified virus was titrated in 10-fold dilutions on A549 cells to measure infectivity directly. (c) MTS assay of each virus to measure impact of transgene expression on cell viability. In all experiments, mean ± SD is plotted (n = 3).
