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Apt 14 inhibits PDGFR-β signaling. Immunoblots of PDGFR-β and PI3K/Akt activation in vascular smooth muscle cell (VSMC) treated in the presence of aptamer (400 nmol/l; 14 or nonselected control (NSC)) following a, PDGF-BB (PDGF; 50 ng/ml). *P < 0.05 versus control. †P < 0.05 versus PDGF. Unst = unstimulated. (b) Immunoblots of PDGFR-α and PDGFR-β following pull-down with biotinylated aptamers (200 nmol/l; 14 or NSC) to VSMCs. Input refers to total lysate.
