Fig 5. REP + siARX cells rescue diabetes in Streptozotocin-treated mice.
Blood glucose levels (A), percentage of body weight loss (B), serum human C-peptide levels (C-D), and intraperitoneal glucose tolerance test (E) of diabetic mice grafted with 5 X 106 REP+siARX cells (n = 5), non-reprogrammed exocrine cells (n = 6) and control non diabetic and non-grafted mice (n = 6). STZ—streptozotocin administration; Tx—time of surgery; Nephrectomy—time of graft removal. Serum samples were collected after 4h starvation (Fast) or ad libitum feeding (Fed) for C-peptide detection. A two way ANOVA was performed followed by a Bonferroni post hoc test, ****P < 0.0001. (F) Immunostaining for C-peptide and glucagon in REP+siARX grafts. Nuclei were counterstained with DAPI. Scale bar = 50 μm.