Table 1. Protein expression (Fold Change) in breast muscle obtained from a single male broiler breeder line individually phenotyped for high or low FE (n = 4 per group).
Positive and negative fold change values indicates proteins that were up-regulated in high FE and low FE broiler males, respectively, with significance level designated by P-values.
| Symbol | Entrez Gene Name | Fold Change | P value |
|---|---|---|---|
| Up-regulated proteins (104 total) in breast muscle obtained from Pedigree Broiler Males exhibiting high FE. | |||
| KRT15 | keratin 15 | 13.70 | 0.036 |
| CACNA1S | calcium channel, voltage-dependent, L type, alpha 1S subunit | 12.08 | 0.004 |
| IDE | insulin-degrading enzyme | 11.69 | 0.004 |
| SLC25A4 | solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4 | 10.32 | 0.002 |
| PHKG1 | phosphorylase kinase, gamma 1 (muscle) | 9.81 | 0.005 |
| CAV1 | caveolin 1, caveolae protein, 22kDa | 9.40 | 0.009 |
| FABP4 | fatty acid binding protein 4, adipocyte | 9.31 | 0.012 |
| CKB | creatine kinase, brain | 8.91 | 0.003 |
| PPA2 | pyrophosphatase (inorganic) 2 | 8.85 | 0.007 |
| ARF4 | ADP-ribosylation factor 4 | 8.81 | 0.004 |
| NDUFV2 | NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa | 8.77 | 0.003 |
| PTRH2 | peptidyl-tRNA hydrolase 2 | 7.78 | 0.001 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 7.68 | 0.015 |
| SNAP23 | synaptosomal-associated protein, 23kDa | 7.55 | 0.008 |
| APRT | adenine phosphoribosyltransferase | 7.28 | 0.038 |
| SAR1B | secretion associated, Ras related GTPase 1B | 6.99 | 0.019 |
| OTUB1 | OTU deubiquitinase, ubiquitin aldehyde binding 1 | 6.66 | 0.051 |
| G3BP1 | GTPase activating protein (SH3 domain) binding protein 1 | 6.59 | 0.002 |
| MYO18A | myosin XVIIIA | 6.50 | 0.017 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | 6.24 | 0.047 |
| RAP1B | RAP1B, member of RAS oncogene family | 6.02 | 0.001 |
| IPO7 | importin 7 | 5.94 | 0.006 |
| ARF1 | ADP-ribosylation factor 1 | 5.75 | 0.010 |
| GLRX3 | glutaredoxin 3 | 5.66 | 0.004 |
| NDUFB8 | NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 8, 19kDa | 5.64 | 0.005 |
| PHKB | phosphorylase kinase, beta | 5.49 | 0.033 |
| SNX3 | sorting nexin 3 | 5.38 | 0.034 |
| DHRS7C | dehydrogenase/reductase (SDR family) member 7C | 5.13 | 0.058 |
| NDUFS7 | NADH dehydrogenase (ubiquinone) Fe-S protein 7, 20kDa (NADH-coenzyme Q Red.) | 4.79 | 0.049 |
| SKP1 | S-phase kinase-associated protein 1 | 4.78 | 0.054 |
| PRPS1 | phosphoribosyl pyrophosphate synthetase 1 | 4.60 | 0.027 |
| TARS | threonyl-tRNA synthetase | 4.52 | 0.017 |
| UBE2H | ubiquitin-conjugating enzyme E2H | 4.29 | 0.028 |
| PTRF | polymerase I and transcript release factor | 4.25 | 0.006 |
| UQCRC1 | ubiquinol-cytochrome c reductase core protein I | 4.11 | 0.059 |
| NME3 | NME/NM23 nucleoside diphosphate kinase 3 | 4.06 | 0.019 |
| GNB2L1 | guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1 | 3.99 | 0.001 |
| RPL30 | ribosomal protein L30 | 3.91 | 0.043 |
| USP9X | ubiquitin specific peptidase 9, X-linked | 3.89 | 0.023 |
| RAB7A | RAB7A, member RAS oncogene family | 3.78 | 0.021 |
| RYR3 | ryanodine receptor 3 | 3.73 | 0.006 |
| SPTB | spectrin, beta, erythrocytic | 3.69 | 0.001 |
| NARS | asparaginyl-tRNA synthetase | 3.60 | 0.014 |
| TPP2 | tripeptidyl peptidase II | 3.58 | 0.048 |
| RAB5B | RAB5B, member RAS oncogene family | 3.52 | 0.033 |
| NUB1 | negative regulator of ubiquitin-like proteins 1 | 3.33 | 0.047 |
| RAB8B | RAB8B, member RAS oncogene family | 3.31 | 0.027 |
| ARL6IP5 | ADP-ribosylation factor-like 6 interacting protein 5 | 3.31 | 0.005 |
| ATP5O | ATP synthase, H+ transporting, mitochondrial F1 complex, O subunit | 3.26 | 0.001 |
| COPS7A | COP9 signalosome subunit 7A | 3.12 | 0.008 |
| GPX1 | glutathione peroxidase 1 | 3.09 | 0.004 |
| CANX | Calnexin | 3.04 | 0.010 |
| VBP1 | von Hippel-Lindau binding protein 1 | 3.02 | 0.024 |
| Cyb5r3 | cytochrome b5 reductase 3 | 3.00 | 0.012 |
| DMD | Dystrophin | 2.87 | 0.000 |
| PRDX3 | peroxiredoxin 3 | 2.85 | 0.008 |
| LYPLA1 | lysophospholipase I | 2.84 | 0.008 |
| VDAC2 | voltage-dependent anion channel 2 | 2.83 | 0.031 |
| PSMD1 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 1 | 2.83 | 0.013 |
| Rrbp1 | ribosome binding protein 1 | 2.76 | 0.050 |
| CTH | cystathionine gamma-lyase | 2.72 | 0.023 |
| PSMD2 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 | 2.70 | 0.035 |
| GLO1 | glyoxalase I | 2.68 | 0.011 |
| FSD2 | fibronectin type III and SPRY domain containing 2 | 2.68 | 0.019 |
| UBE2N | ubiquitin-conjugating enzyme E2N | 2.66 | 0.010 |
| COX4I1 | cytochrome c oxidase subunit IV isoform 1 | 2.63 | 0.019 |
| CUL3 | cullin 3 | 2.61 | 0.015 |
| GLUD1 | glutamate dehydrogenase 1 | 2.60 | 0.001 |
| DCUN1D2 | DCN1, defective in cullin neddylation 1, domain containing 2 | 2.60 | 0.050 |
| LANCL2 | LanC lantibiotic synthetase component C-like 2 (bacterial) | 2.58 | 0.059 |
| Ktn1 | kinectin 1 | 2.57 | 0.027 |
| SGCG | sarcoglycan, gamma (35kDa dystrophin-associated glycoprotein) | 2.51 | 0.048 |
| CARS | cysteinyl-tRNA synthetase | 2.49 | 0.018 |
| RAB12 | RAB12, member RAS oncogene family | 2.44 | 0.049 |
| UQCRC2 | ubiquinol-cytochrome c reductase core protein II | 2.41 | 0.003 |
| VDAC1 | voltage-dependent anion channel 1 | 2.40 | 0.004 |
| EIF3B | eukaryotic translation initiation factor 3, subunit B | 2.37 | 0.042 |
| CISD2 | CDGSH iron sulfur domain 2 | 2.30 | 0.009 |
| OARD1 | O-acyl-ADP-ribose deacylase 1 | 2.29 | 0.029 |
| KLHL40 | kelch-like family member 40 | 2.28 | 0.046 |
| OGDH | oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) | 2.26 | 0.028 |
| PPIB | peptidylprolyl isomerase B (cyclophilin B) | 2.24 | 0.020 |
| CSPG4 | chondroitin sulfate proteoglycan 4 | 2.13 | 0.045 |
| YWHAG | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma | 2.10 | 0.016 |
| YWHAH | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta | 2.07 | 0.015 |
| TMED10 | transmembrane emp24-like trafficking protein 10 (yeast) | 2.06 | 0.007 |
| ALDH1L2 | aldehyde dehydrogenase 1 family, member L2 | 2.05 | 0.018 |
| PSMB1 | proteasome (prosome, macropain) subunit, beta type, 1 | 2.02 | 0.044 |
| EMC2 | ER membrane protein complex subunit 2 | 1.98 | 0.030 |
| RPL12 | ribosomal protein L12 | 1.98 | 0.009 |
| HSPB2 | heat shock 27kDa protein 2 | 1.96 | 0.028 |
| DHRS7B | dehydrogenase/reductase (SDR family) member 7B | 1.96 | 0.037 |
| ATP2B4 | ATPase, Ca++ transporting, plasma membrane 4 | 1.93 | 0.013 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 1.86 | 0.031 |
| PFKM | phosphofructokinase, muscle | 1.86 | 0.001 |
| MYOM2 | myomesin 2 | 1.84 | 0.007 |
| MYLK2 | myosin light chain kinase 2 | 1.83 | 0.039 |
| DDX1 | DEAD (Asp-Glu-Ala-Asp) box helicase 1 | 1.80 | 0.018 |
| PSMA5 | proteasome (prosome, macropain) subunit, alpha type, 5 | 1.79 | 0.019 |
| BAG3 | BCL2-associated athanogene 3 | 1.76 | 0.034 |
| SRL | Sarcalumenin | 1.71 | 0.006 |
| AMPD1 | adenosine monophosphate deaminase 1 | 1.68 | 0.046 |
| NDUFS8 | NADH dehydrogenase (ubiquinone) Fe-S protein 8, 23kDa (NADH-coenzyme Q) | 1.61 | 0.014 |
| CACNA2D1 | calcium channel, voltage-dependent, alpha 2/delta subunit 1 | 1.57 | 0.053 |
| ANXA4 | annexin A4 | 1.54 | 0.025 |
| Down-regulated proteins (47) in breast muscle obtained from Pedigree Male broilers exhibiting high FE. | |||
| DCTN2 | dynactin 2 (p50) | -11.19 | 0.006 |
| UBQLN4 | ubiquilin 4 | -7.95 | 0.012 |
| SPINK5 | serine peptidase inhibitor, Kazal type 5 | -7.61 | 0.015 |
| BCAP29 | B-cell receptor-associated protein 29 | -7.24 | 0.018 |
| CAPZA2 | capping protein (actin filament) muscle Z-line, alpha 2 | -5.93 | 0.038 |
| C4BPA | complement component 4 binding protein, alpha | -5.62 | 0.012 |
| EIF4G1 | eukaryotic translation initiation factor 4 gamma, 1 | -5.06 | 0.014 |
| EDF1 | endothelial differentiation-related factor 1 | -3.88 | 0.033 |
| ALDH9A1 | aldehyde dehydrogenase 9 family, member A1 | -3.85 | 0.029 |
| USP15 | ubiquitin specific peptidase 15 | -3.77 | 0.026 |
| SMYD1 | SET and MYND domain containing 1 | -3.74 | 0.028 |
| EML1 | echinoderm microtubule associated protein like 1 | -3.24 | 0.015 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -3.23 | 0.008 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -3.20 | 0.018 |
| ACTA1 | actin, alpha 1, skeletal muscle | -2.89 | 0.000 |
| UBE2V1 | ubiquitin-conjugating enzyme E2 variant 1 | -2.85 | 0.019 |
| SOD1 | superoxide dismutase 1, soluble | -2.81 | 0.015 |
| PABPC4 | poly(A) binding protein, cytoplasmic 4 (inducible form) | -2.76 | 0.009 |
| ACTC1 | actin, alpha, cardiac muscle 1 | -2.71 | 0.000 |
| MYBPC2 | myosin binding protein C, fast type | -2.59 | 0.000 |
| ALB | Albumin | -2.57 | 0.004 |
| FKBP4 | FK506 binding protein 4, 59kDa | -2.51 | 0.058 |
| IQGAP1 | IQ motif containing GTPase activating protein 1 | -2.46 | 0.163 |
| ACTG1 | actin, gamma 1 | -2.32 | 0.012 |
| MYL1 | myosin, light chain 1, alkali; skeletal, fast | -2.09 | 0.001 |
| PEPD | peptidase D | -2.09 | 0.004 |
| SARS | seryl-tRNA synthetase | -2.08 | 0.031 |
| CAMK2D | calcium/calmodulin-dependent protein kinase II delta | -2.05 | 0.015 |
| APOA1 | apolipoprotein A-I | -2.00 | 0.057 |
| PACSIN3 | protein kinase C and casein kinase substrate in neurons 3 | -1.81 | 0.011 |
| FBP2 | fructose-1,6-bisphosphatase 2 | -1.77 | 0.008 |
| NAP1L4 | nucleosome assembly protein 1-like 4 | -1.75 | 0.024 |
| CCT2 | cell division cycle 42 | -1.67 | 0.010 |
| RAB11A | RAB11A, member RAS oncogene family | -1.67 | 0.032 |
| CCT2 | chaperonin containing TCP1, subunit 2 (beta) | -1.64 | 0.002 |
| GPI | glucose-6-phosphate isomerase | -1.59 | 0.043 |
| ENO2 | enolase 2 (gamma, neuronal) | -1.58 | 0.044 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | -1.52 | 0.029 |
| PBLD | phenazine biosynthesis-like protein domain containing | -1.49 | 0.044 |
| LDB3 | LIM domain binding 3 | -1.49 | 0.019 |
| EIF4A2 | eukaryotic translation initiation factor 4A2 | -1.49 | 0.015 |
| HN1L | hematological and neurological expressed 1-like | -1.46 | 0.040 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -1.45 | 0.055 |
| EEF1A2 | eukaryotic translation elongation factor 1 alpha 2 | -1.44 | 0.015 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -1.44 | 0.052 |
| CKM | creatine kinase, muscle | -1.41 | 0.036 |
| CAP2 | CAP, adenylate cyclase-associated protein, 2 (yeast) | -1.31 | 0.014 |