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. 2016 May 24;11:2251–2264. doi: 10.2147/IJN.S102268

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© 2016 Ren et al. This work is published and licensed by Dove Medical Press Limited

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The effects of SiNPs on the expression of proteins in RIPK1 signal pathway at 45 days.

Notes: (A) The expression of RIPK1/FADD/caspase-8/cleaved caspase-8/caspase-3/cleaved caspase-3 and RIPK3/MLKL were measured by Western blot assay. (B) Relative densitometric analysis of protein bands were presented. After being exposed to SiNPs for 45 days, SiNPs upregulated the expressions of RIPK1/FADD/caspase-8/cleaved caspase-8/caspase-3/cleaved caspase-3 and RIPK3/MLKL. Data are expressed as the mean ± standard error from three independent experiments. *P<0.05 vs the saline control group. The data indicated that SiNPs could increase the expression of proteins in the RIPK1 signal pathway.

Abbreviations: SiNPs, silica nanoparticles; FasL, Fas ligand; C-caspase-8, cleaved caspase-8; C-caspase-3, cleaved caspase-3.