Table 1.
The IC50 of sorafenib solution, sorafenib-LNS, and blank-LNS for HepG2 and Bel-7402 cells after 48 hours incubation
| Cell line | Sorafenib solution (μM) | Sorafenib-LNS (μM) |
|---|---|---|
| HepG2 | 8.61±1.46 | 3.39±0.56** |
| Bel-7402 | 10.01±1.11 | 2.65±0.30** |
Notes: The cytotoxicity was tested using the MTT assay, and the sorafenib concentration was 0.5–20 μM. All the data are presented as mean ± SD (n=3; **P<0.01, compared with sorafenib solution).
Abbreviations: blank-LNS, blank lipid-based nanosuspensions; MTT, 3-(4-5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide; sorafenib-LNS, sorafenib-loaded lipid-based nanosuspensions; IC50, the half-maximal inhibitory concentration.